Adobe is trying to revamp Flash 11 and Air 3 to make them more web-based game friendly. This time, with WebGL API. We will see how it goes.
Meanwhile, Unity3D is chugging along, and doing very well as a multi-device development platform, running on Wii, iPad, Android and desktops (PC/Mac).
Meanwhile, I should also check out Spongelab, an interactive game-for-learning company as mentioned in this Scientific American blog.